CD4 and infection: The figure shows that over thecourse of infection, there is a general narrowing of the absolute breadth ofresponses (Figure 1a).However, the relative contribution of Gag to the total responses decreased(p<0.0001, r2 = 0.055) in contrast to theproportion of responses to other proteins such as Env (p<0.0001,r2 = 0.024) and Vif(p = 0.003, r2 = 0.011),which was greater in patients with lower CD4 cell counts.