Guibal et al [78] showed that in a murine model of acute promyelocytic leukemia (APL), a population of committed myeloid cells (CD34+, c-kit+, FcγRIII/II+, Gr1int) demonstrated enhanced self-renewal capacity through the down-regulation of the transcription factor CCAAT/enhancer binding protein-α(C/EBP-α) and were capable of efficiently generating leukemia in recipient mice. The gene discussed is CD34; the disease is leukemia.