In 1997, Bonnet et al [10] isolated two groups of leukemia cells from leukemia patients with specific surface markers CD34 and CD38, and found that CD34+CD38- leukemia cells had the capacity of self-renewal and multi-differentiation similar to hematopoietic stem cells, and developed tumor more quickly than CD34-CD38+ leukemia cells. Here, CD34 is linked to leukemia.