Accordingly, the blockade or absence of P2X7 receptors were found to be neuroprotective in animal models of spinal cord injury [17,18], Alzheimer's disease (AD) [19] and Huntington's disease [20], but conflicting results have been found in animal models of ischemia-reperfusion ([21,22] but see [23,24]) and multiple sclerosis ([25] but see [26,27]). This evidence concerns the gene P2RX7 and juvenile Huntington disease.