Note that with FGF-23 antibody treatments, the diffuse fluorochrome labeling pattern normally seen in the Dmp1 KO mice (and other models of osteomalacia) is restored to a pattern resembling that in control mice, with discrete lines of calcein and alizarin red labeling, suggesting a more normal bone-formation rate (Fig. 6A). This evidence concerns the gene DMP1 and osteomalacia.