HTT and neurodegenerative disease: We have compared geneticmodifiers from other yeast models and found that these five genes are not identifiedas suppressors in other yeast models for neurodegenerative diseases, includingParkinson's disease (over-expression of α-synuclein [25]), TDP-43-dependent ALS(over-expression of wild-type TDP-43 [28]), and Huntington'sdisease (over-expression of polyQ-expanded huntingtin [24]), indicating that they arespecific to FUS/TLS.