To elucidate novel mechanisms contributing to the HTLV-1neurological complex and its classic neurological presentation called HAM/TSP(HTLV-1 associated myelopathy/tropical spastic paraparesis), we investigated theexpression of the Tim-3 receptor on CD8+ T cells from a cohortof HTLV-1 seropositive asymptomatic and symptomatic patients. Here, CD8A is linked to Myelopathy.