We evaluated the expression and co-expression of Tim-3 andPD-1 on T cells derived from HTLV-1 seropositive (both asymptomatic carriers andpatients with the diagnosis of HAM/TSP) and seronegative controls to determinewhether they were modulated in HTLV-1 infection. This evidence concerns the gene HAVCR2 and tropical spastic paraparesis.