With regards to the known inhibitory effects of IM on Abcg2, our studies suggest that the additive effects of Danusertib and IM on the emergence of resistant clones in vitro and on proliferation of primary CML stem and progenitor cells can be based on the accumulation of Danusertib in Abcg2 expressing cells [10]. Here, ABCG2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.