Additionally, mesothelioma cells also showed nicotine-stimulated proliferation through α7-nAChR-mediated Ca2+-dependent activation of the ERK1-ERK2 cascade and inhibited apoptosis by induction of NF-κB and phosphorylation of BAD at Ser112 (Bcl-2 antagonist of cell death) [32]. The gene discussed is CHRNA7; the disease is mesothelioma.