CD44 and malignant peripheral nerve sheath tumor: Adriamycin resistance of leukemic cells was effectively reversed by HA-4 oligomers by increasing the intracellular accumulation of adriamycin [138], whilst in malignant peripheral nerve sheath tumors (MPNST), HA oligomers resulted in the disassembly of CD44-transporter complexes and induced internalization of CD44 [139].