On the other hand, possible regulation of other cancer-germline (CG) or cancer-testis antigen genes by BORIS was recently investigated but it was shown that BORIS expression is not sufficient for induction of CG antigen gene expression and DNA hypomethylation in their promoter in ovarian cell lines, suggesting the involvement of additional mechanisms in the regulation of CG antigen expression in ovarian cancer [80]. The gene discussed is CTSG; the disease is ovarian carcinoma.