CTCFL and ovarian cancer: In ovarian cancer, it has been reported that the following cancer-promoting genes are overexpressed in association with promoter DNA hypomethylation: SNGG (synucelin-γ), encoding an activator of the MAPK and Elk-1 signaling cascades [77,78], BORIS (brother of the regulator of imprinted sites), a cancer-testis antigen gene and a paralog of CTCF [79] (Table 2).