Animal models (Kim et al, 1993; Huang et al, 2004; Mancuso et al, 2006) and human studies (Willett et al, 2004) have shown that blocking VEGF signalling results in tumour shrinkage, associated with the pruning of angiogenic (proliferative, leaky and immature (i.e., without associated pericytes)) blood vessels. The gene discussed is VEGFA; the disease is neoplasm.