However, CrPic was reported to enhance skeletal muscle glucose transporter-4 (GLUT-4) translocation and insulin sensitivity in a rat model of obesity and insulin resistance [44] and also recruits intracellular localization of GLUT-4 to the cytoplasmic side of the plasma membrane of murine adipocytes [45]. This evidence concerns the gene SLC2A4 and obesity due to melanocortin 4 receptor deficiency.