When cyclin D1 expression was analysed in relation to clinicopathological features of oral cancer patients (Table) it was found that expression cyclin D1 was significantly associated with advanced age (>50 yr) at the time of presentation ((P<0.02) higher tumour stage (T3, T4; (P<0.01) and lymph node metastasis ((P<0.01). This evidence concerns the gene CCND1 and metastatic malignant neoplasm in the lymph nodes.