TLR9 and neoplasm: CpG-ODN can suppress apoptosis of macrophages via TLR9 through PKB/Akt/FOXO pathway [22], since macrophages and T cells play an important role in anti-tumor immune, our study showed CpG-ODN suppresses apoptosis through FasL/Fas pathway, maybe PKB/Akt/FOXO is another way in anti-apoptosis anti-cancer therapeutic strategies of CpG-ODN.