KRAS and viral infectious disease: Due to its high suppression efficiency and sequence specificity up to a single nucleotide resolution [13] has encouraged the development of RNAi-based therapeutic models for possible use in viral infections i.e. HIV-1 [32], HBV [22], HCV [22], respiratory viruses [33] and cancer i.e. K-ras [34], PI 3-kinase [31].