We used a ds-RNA to interfere with the expression of MMP-9 gene in CML MSC and our findings support the conclusion that MMP-9 constitutes a trigger for the switch between adhesive and invasive states in CML MSC by changing the ICAM-1 from membrane-anchored state to solvable one leading to tumor cell immune evasion and metastasis. This evidence concerns the gene ICAM1 and chronic myelogenous leukemia, BCR-ABL1 positive.