NOS2 and brain ischemia: Available evidence revealed that components of Yiqifumai are effective for prevention and recovery of shock, ischemic and oxidative damage in the brain during heatstroke [5], able to protect against heat stroke-induced arterial hypotension and cerebral ischemia by inhibition of inducible nitric oxide synthase (iNOS)-dependent nitric oxide (NO) overproduction in the brain and excessive accumulation of inflammatory cytokines in the peripheral blood [6].