In both datasets we observed a significant enrichment in expression of N-Myc target genes in C5 tumours (AOCS p<0.0001, TCGA p<0.0001, one-sided Fisher's exact test, Figure 3C), including trans-activation of LIN28B. MYCN and HMGA2 expression were also highly significantly correlated (Figure S3). The gene discussed is HMGA2; the disease is neoplasm.