VEGFA and corneal disorder: Thus, we raised a question “do gene transfer parameters optimized using normal rabbit corneas are applicable for the diseased cornea?” To answer this question we used two most acceptable in vivo rabbit disease models; the PRK-based corneal scarring model and the VEGF-induced corneal neovascularization model to test the potential of optimized tissue-targeted gene transfer approaches using AAV5 for treating corneal diseases such as corneal fibrosis and corneal neovascularization.