In a recent glioma GWA study Shete and colleagues identified low-penetrance susceptibility loci harboring TERT (Swiss-Prot: O14746, Q9UNR4, Q8NG38, Q9UBR6, Q9UNS6), CCDC26 (Swiss-Prot: Q8TAB7), CDKN2A (Swiss-Prot: Q8N726, P42771, Q208B5, Q5ZEY9, Q9UPB7, A7LNE7, A5X2G7, Q2MJK0), CDKN2B (Swiss-Prot: P42772, Q5ZEY8, O15125, Q8NIA6, Q9UM95), RTEL1 (Swiss-Prot: Q9BW37 Q9NZ71) and PHLDB1 (Swiss-Prot: Q86UU1, B0YJ63, B0YJ65) with elevated risk of glioma [5]. The gene discussed is RTEL1; the disease is central nervous system cancer.