Indeed, one child with partial recessive IFN-γR1 deficiency, and others with IL-12p40 deficiency, XR-MSMD1 (NEMO deficiency) and XR-MSMD2 (CYBB deficiency) associated with clinical TB have been identified [21], [23]. This evidence concerns the gene IFNGR1 and hyperinsulinemic hypoglycemia, familial, 4.