An older brother was found to be homozygous for the mutant allele of IL12RB1. This brother had been vaccinated with BCG, with no adverse effect, and developed cutaneous leishmaniasis at the age of seven years and scrofuloderma of the neck at the age of 12 years, which was successfully treated with antimycobacterial drugs (rifampin and isoniazid supplemented with streptomycin for the first two months). Here, IL12RB1 is linked to cutaneous leishmaniasis.