AGPAT2 and Berardinelli-Seip congenital lipodystrophy: Berardinelli-Seip Congenital Lipodystrophy (BSCL), the most severe form of lipodystrophy in humans, is caused by mutations in either BSCL1 or BSCL2. BSCL1 encodes acylglycerol phosphate acyltransferase 2 (AGPAT2), which is involved in triacylglycerol (TAG) biosynthesis, while BSCL2 encodes Seipin [11], [12].