Of note,several existing vaccines trigger TLRs: Bacillus Calmette Guerin(BCG), the most widely used vaccine against TB with an established safety andefficacy profile activates TLR2, -4 and -8 [28]–[30] and the meningococcal outermembrane protein complex used to adjuvant the Haemophilus conjugate vaccine, wassubsequently shown to be a TLR2 agonist [31]. Here, TLR2 is linked to tuberculosis.