In order to learn whether other MD-genes, which are not directly related to dystrophin, might also suppress tumor formation, we studied mice lacking dysferlin (DysfSJL mutation [8]; Dysf −/−), calpain-3 (Capn3 −/−; knockout [11]), or Large (Largemyd mutation [12]; Large −/−). Here, CAPN3 is linked to neoplasm.