Since L. rhamnosus Lcr35 modulates the Th1/Th2 balance towards the Th1(/Th17) response in DCs, it could counter-regulate the impaired cytokine profile observed in IgE-dependent allergies, characterized by an imbalance of the Th1/Th2 response towards the Th2 profile. The gene discussed is IGHE; the disease is allergic disease.