Furthermore, a significant differential expression (DE) of snoRNAs in humantrisomic EPCs (compared to euploid) was also observed (Table S4).In particular, 46 C/D box snoRNAs (3 up- and 43 down-regulated), 31 H/ACA box (9up- and 22 down-regulated) and 9 Cajal body-specific scaRNAs (2 up- and 7down-regulated) were differentially expressed in DS compared to euploid cells.Interestingly, we noted that the gene with the highest expression of HSA21 was amember of H/ACA box, SNORA80, which showed a strong evidence ofDE in the trisomic cells. The gene discussed is SNORA80A; the disease is Dravet syndrome.