FOS and obesity due to melanocortin 4 receptor deficiency: The reduced levels of PUFA n3intake in FOS subjects possibly bias associations toward significance of maineffects, while biasing against significance for interaction with PUFA n3.Identifying the function(s) of miR-522 and the conditions that induce its activationand repression will help clarify its role in mammalian development and as apotential modulator of obesity phenotypes.