COL8A2 and Fuchs endothelial corneal dystrophy: The first gene to becausally linked with FECD was COL8A2 (MIM: 120252) on chromosome 1,in which two missense mutations, p.L450W and p.Q455V/Q455K, have been replicated inrare early-onset (before 40 years of age) FECD multigenerational families [3], [13]–[15] and in atypical sporadicFECD cases [15].