IFI35 and systemic lupus erythematosus: Amongst the list of 11 Carg4 positional candidates whose expression is regulated by IFNγ and which display IFNγ regulated STAT1 recruitment to their promoters (Table S3), we note the presence of Ifi35. Ifi35 belongs to the family of interferon-inducible proteins, a group of proteins whose expression is rapidly induced by both type I and type II interferons, and that have been associated with different pathologies including systemic lupus erythematosus [57], cancer [58], and antiviral host defense [59].