Since it was clear that all the control Akita mice would be dead within 2 months (consistent with other survival curves of mice with Type 1 diabetes [24]), when we anticipated the Akita mice would be sacrificed, thus preventing post-sacrifice comparison of kidney oxidative stress and histology, we elected to sacrifice all mice on the control diet (wild-type and Akita), and to continue to monitor blood glucose and urinary albumin/creatinine ratios in mice on the ketogenic diet. The gene discussed is ALB; the disease is type 1 diabetes mellitus.