CDH1 and neoplasm: The critical hallmarks of EMT include the down-regulation of E-cadherin which is considered to be a tumor suppressor gene [10], activation of Rho small GTPases such as Rac1/RhoA which may increase cell motility by up-regulating actin turnover and formation of focal adhesion [11], cytoskeletal rearrangement and nuclear translocation of several transcription factors such as Snail and Twist [12], [13].