In addition, during infection with Yp-YopJCO92 orYp-YopJC172A, higher amounts of IL-1β were secreted fromIkkβΔ BMDMs as compared toIkkβF/F macrophages (Figure 4B), consistent with the idea that theNF-κB pathway negatively regulates processing and secretion of IL-1β viacontrol of caspase-1 activation [7]. The gene discussed is CASP1; the disease is infection.