NLRP3- orASC-deficient BMDMs infected with Yp-YopJKIM secreted significantlylower levels of IL-1β and IL-18 as compared to wild-type macrophagesinfected with Yp-YopJKIM (Figure 7A,B; Figure S7A, B in Text S1).NLRC4-deficient macrophages released similar levels of these cytokines ascompared to wild-type BMDMs (Figure7A, Figure S7A in Text S1), suggesting that NLRC4 does not playa significant role in caspase-1 activation and cytokine secretion duringYp-YopJKIM infection. The gene discussed is CASP1; the disease is infection.