CASP1 and infection: However, like other NLRP3 activators such as nigericin,caspase-1 activation in response to Yp-YopJKIM infection did not requireP2X7R. One possibility is that pore formation duringYopJKIM-induced apoptosis leads to K+ efflux,resulting in activation of the NALP3/ASC/caspase-1 inflammasome.