THBS1 and schistosomiasis: Sjc23, a member of the tetraspanin (TSP) familyof Schistosoma japonicum, was previously found to be highlyimmunogenic and regarded as a vaccine candidate against schistosomiasis.However, studies indicated that immunization with Sjc23 generated rapidantibody responses which were less protective than that with other antigens.The biological function of this membrane-anchored molecule has not beendefined after decades of vaccination studies.