Accordingly, over-expression of ZEB2 and TWIST1 in surgical samples of both normal and tumor tissues can induce EMT, resulting in over-expression of representative EMT markers VIM, FN, and COLs (Figures 2, 4, 6, S2, and S3) and membrane signal transducers IL8, CXCL4, CCL5, CXCR4, PDGFRB, and TLR2 (Figure 2). This evidence concerns the gene CXCR4 and neoplasm.