Replicatedgenes include ARHGAP1, CTNNB1, ESR1, FAM3C, FLJ42280, FOXL1, GPR177, HDAC5,JAG1, LRP5, MARK3, MEF2C, MEPE, OPG, RANK, RANKL, SOST, SOX6, SP7(Osterix), STARD3NL and ZBTB40. Considering thecombined Anglo-Australasian Osteoporosis Genetics Consortium (AOGC) anddeCODE/TwinsUK/Rotterdam cohorts, 97 SNPs from six loci achievedP<5×10−8 at the femoral neck (FN), of which four hadpreviously been reported (FLJ42280, MEF2C, SOX6, ZBTB40). The gene discussed is ESR1; the disease is osteoporosis.