Mutations of CLCN7 cause a family of osteopetroses of differing ageof presentation and severity, including infantile malignantCLCN7-related recessive osteopetrosis (ARO), intermediate autosomalosteopetrosis (IAO), and autosomal dominant osteopetrosis type II (ADOII,Albers-Schoenberg disease). This evidence concerns the gene CLCN7 and autosomal dominant osteopetrosis 2.