For example, IL-1β is a potent inducer of TNFα, a major stimulant of apoptosis and inflammation, and an anti-TNFα monoclonal antibody, infliximab, has shown promising results in controlling symptoms of PAPA syndrome, including dramatic resolution of severe pyoderma gangrenosum in one patient [59-61]. The gene discussed is TNF; the disease is pyoderma gangrenosum.