The polymorphism at position -634 was found to be associated with ventricular septal defects in a Chinese population [53] and two other VEGF SNPs (-460T/C and +405G/C) also associated with decreased VEGF expression have been reported to be associated with valvuloseptal defects in a small case-control study [54]. This evidence concerns the gene VEGFA and ventricular septal defect 1.