TPO and Autoimmunity: Specifically, we speculate that patients withthyroid autoimmunity and IgG autoantibodies to thyroid antigens can also exhibit IgEautoantibodies to these autoantigens that then function as ‘autoallergens’.To test our hypothesis, we have developed an ELISA-based detection assay for IgEantibodies to thyroid peroxidase (TPO) and we have tested csU patients and healthysubjects for the presence of these IgE autoantibodies to TPO (IgE-anti-TPO).