To address the need for more comprehensive treatment of type 2 diabetes, recent algorithms developed by the AACE and ADA/European Association for the Study of Diabetes have recommended the use of glucagon-like peptide-1 (GLP-1) receptor agonists (monotherapy or combination therapy) on the basis of their effective glycemic control, weight loss effects, low rates of hypoglycemia, and overall safety profiles, and particularly for use in patients for whom hypoglycemia is especially undesirable or promotion of weight loss is a major consideration [2,9,11]. The gene discussed is GCG; the disease is Hypoglycemia.