Laminin 5 is the only laminin that contains the γ2 chain, which following cleavage into promigratory fragments, the domain III region, causes increased levels of matrix metalloproteinase-2 (MMP-2), and matrix metalloproteinase-14 (MMP-14) cooperate to cleave γ2 chain into fragments that promote melanoma cell invasion and VM [43,44]. The gene discussed is MMP14; the disease is melanoma.