BDNF and Alzheimer disease: Twenty-eight children with AD were treated with PentaHerbs for three months, and their mean plasma concentrations of BDNF and TARC decreased significantly from 1798 pg/mL and 824 pg/mL at baseline to 1378 pg/mL and 492 pg/mL (P = 0.002 and 0.013 respectively) upon study completion.