Recently, LDLR-/- mice transplanted with TLR2-/- TLR4-/- bone marrow displayed a reduction in both macrophage apoptosis and atherosclerotic plaque necrosis as compared with LDLR-/- mice transplanted with wild-type bone marrow, supporting an additive effect of TLR2 and TLR4 in murine atherosclerosis [112]. This evidence concerns the gene TLR4 and atherosclerosis.