NUDE mice (in opposition to their nu/+ littermates) showed similar clinical signs of infection to Rag1−/− mice, including decreased activities, disseminated lesions in the tail (data not shown) and significant weight loss (p<0.001, unpaired t test, Figure 6A), culminating with the death of all animals in the group (Mean survival: 17 days, p<0.001 compared to nu/+ animals, Figure 6B). The gene discussed is RAG1; the disease is infection.