To assess the potential of the analytes for identifying very mild/mild dementia (combined CDR 0.5 and CDR 1), ROC curves and AUCs were calculated for each of the 37 RBM analytes and for traditional AD biomarkers Aβ42, tau, p-tau181 and the ratios tau/Aβ42 and p-tau181/Aβ42 (Table 4 and Figure 1). This evidence concerns the gene MAPT and Alzheimer disease.