No mutations onthe RAF1 gene were identified in negative cases ofPTPN11, SOS1, and KRAS.Patients #39 and #41 were posteriorly diagnosed with suffering from LEOPARDsyndrome, and in fact, they carried the characteristic mutations on genesPTPN11 (Figure1, Supplementary Table S1). The gene discussed is SOS1; the disease is Noonan syndrome with multiple lentigines.