No mutations onthe RAF1 gene were identified in negative cases ofPTPN11, SOS1, and KRAS.Patients #39 and #41 were posteriorly diagnosed with suffering from LEOPARDsyndrome, and in fact, they carried the characteristic mutations on genesPTPN11 (Figure1, Supplementary Table S1). Here, RAF1 is linked to Noonan syndrome with multiple lentigines.