Several genes have been reported to be associated with this disease, including complement factor H [2]–[4] and the age-related maculopathy susceptibility 2/HtrA serine peptidase 1 (ARMS2/HTRA1) region [5], [6], and subsequent studies have replicated the association between susceptibility genes and the development of AMD using a different ethnic cohort [7]–[10]. This evidence concerns the gene HTRA1 and age-related macular degeneration.