Although we compared the genotype distributions of rs2511989 in typical AMD and PCV patients against 2 independent control groups (cataract patients without ARM and healthy Japanese individuals), SERPING1 rs2511989 was not significantly associated with typical AMD (P = 0.932 and 0.513, respectively); furthermore, it was not significantly associated with PCV (P = 0.505 and 0.141, respectively). This evidence concerns the gene SERPING1 and age-related macular degeneration.