In clinical practice, immunohistochemistry on tissue biopsies and ELISA-based detection of circulating SCCA (including both SCCA1 and SCCA2) are currently used as valuable predictors of nodal metastasis, response to treatment, and tumor recurrence in SCCs of the uterine cervix, lung, head and neck, esophagus, and liver [5], [6]. The gene discussed is SERPINB4; the disease is neoplasm.