PVT1 may also regulate other ECM components and key ECM regulators not addressed in this study, particularly those detected mainly in late glomerulosclerosis (21), including collagen type I and III, matrix metalloproteinases MMP3, MMP7, MMP10 and MMP1 [49], as well as the proteoglycans, decorin, versican, and perlecan [20]. Here, PVT1 is linked to glomerulosclerosis.