PVT1 and cancer: To date, most investigations of PVT1 have been conducted in respect to cancer, particularly lymphomas and breast/ovarian tumors, and little is known of the role of PVT1 in normal tissues, In humans, PVT1 has been shown to play a role in cell proliferation and apoptosis, and it is likely that the tumorigenic properties of PVT1 are manifested, at least in part, through this activity.