PVT1 may also regulate other ECM components and key ECM regulators not addressed in this study, particularly those detected mainly in late glomerulosclerosis (21), including collagen type I and III, matrix metalloproteinases MMP3, MMP7, MMP10 and MMP1 [49], as well as the proteoglycans, decorin, versican, and perlecan [20]. The gene discussed is VCAN; the disease is glomerulosclerosis.