FN1 and diabetic kidney disease: Importantly, miRNAs have been shown to mediate TGFB signaling in diabetic nephropathy, and several candidates, including miR-92, miR-192, miR-216a, miR-217, and miR-377 are upregulated in mesangial cells in response to either glucose or TGFB, and are also indirectly correlated with increased collagen and fibronectin expression [44], [45], [46], [47].