SERPINC1 and Sepsis: APC treatment of PAR1 KO mice challenged with LPS reproducibly prolonged the time of survival in a study by Kerschen et al.38 In addition, the selective direct thrombin inhibitor Hirudin decreases sepsis mortality and fibrin deposition in animal models of sepsis.15 Interestingly, partial KO mouse strains e.g. AT III+/-and (or) PC+/-challenged with endotoxin exhibit increased mortality and fibrin deposition.39, 40