Interestingly, in PAR single-knockout (KO) mice (PAR 1, PAR 2, and PAR 4 KO) and in double-KOs e.g. PAR 1: PAR 2 and PAR 2: PAR 4 neither single PAR deficiency nor combined PAR deficiency (such as PAR 1: PAR 2 or PAR 2: PAR 4) had any significant role in mouse survival during LPS-induced endotoxemia.19 PAR (PAR 1-PAR 4) receptors expressed on circulating cells rather than on tissue cells i.e. cardiomyocyte, pneumocytes, neurons etc, at different stages of its activation and in different amounts, regulate the endotoxemic-coagualtion-innate inflammatory response through activity of its TLR’s. The gene discussed is F2RL3; the disease is serum lipopolysaccharide activity.