Multiple stepwise regression analysis revealed that plasma FGF21 was independently associated with BUN, Phosphate, LVMI and β2 microglobulin adjustment for age, gender and BMI in all CKD subjects (P≤0.043, respectively, Table 4), thus all other parameters including gender, BMI, diabetes, systolic pressure, CCR, eGFR, creatinine, BUN, CRP, adiponectin, CXCL16, triglyceride, total cholesterol, LDL, HDL, proteinuria, fasting glucose, albumin, LVDd and LVH were excluded during regression analysis. This evidence concerns the gene FGF21 and diabetes mellitus.