In the present study, our data indicated that plasma FGF21 levels are independently associated with β2 microglobulin, and were significantly associated with eGFR, CCR, creatinine and BUN in CKD subjects(Figure 4), suggesting that elevated FGF21 levels are closely related to the injury of glamorous and the change of renal function in CKD patients. This evidence concerns the gene FGF21 and chronic kidney disease.